The Rare Disease Database

The most comprehensive source of rare disease information.

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Top 10 rare neurological diseases

Measured by: prevalence

DiseaseEst US prevalenceInheritanceAge of onset
Narcolepsy146,000 – 200,000
Idiopathic hypersomnia104,280 – 130,000
Charcot-Marie-Tooth disease82,250 – 125,000
Myasthenia-Gravis48,000 – 60,000
Young onset parkinson’s disease40,000 – 50,000
Lennox-Gastaut syndrome30,000 – 45,000
Tuberous sclerosis27,000 – 37,500
Huntington disease21,450 – 30,000
Progressive supranuclear palsy21,000 – 45,870
Amyotrophic lateral sclerosis15,000 – 17,500