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5 Facts you should know about

Activated PI3K delta syndrome (APDS)

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1

APDS, a Primary Immunodeficiency, was only characterized in 2013, although it shares many features of other immune disorders, which means APDS patients may have been previously misdiagnosed with other conditions

APDS patients may have been previously misdiagnosed with other conditions

2

Signs and symptoms of APDS start in childhood,

and patients are vulnerable to repeat infections and immune dysregulation such as sinusitis, severe respiratory tract infections, recurrent herpes or EBV/CMV, lymphadenopathy, and autoimmune cytopenias

3

Immunologists may mistake APDS for combined immunodeficiency (CID)

or common variable immune deficiency (CVID) or hyper IgM syndrome (HIGM)

4

Genetic testing is the only way to definitively diagnose APDS and other primary immunodeficiencies

5

Management of APDS is symptomatic—

antibiotics, antivirals, or IVIG may be used to treat or prevent recurrent infections immunodeficiencies

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