Rare Medical News

5 Facts you should know about

Alagille syndrome



An inherited liver disorder that also affects the heart, eyes, bones, kidneys, vasculature and other organs.


Individuals with AGS may have characteristic facial features, including prominent forehead and pointed chin, deep-set eyes and a straight nose.


An estimated 15% of people diagnosed with Alagille syndrome are at risk of severe liver disease and liver failure that can be life-threatening.


A problem with the JAG1 gene - usually a mutation in, but sometimes a deletion - causes more than 90% of Alagille syndrome cases.


Itchiness is often a very challenging symptom in Alagille syndrome

some patients scratch so hard and so frequently that it causes red marks, bleeding, and scarring.

Rare Medical News