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5 Facts you should know about

Alagille syndrome

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1

An inherited liver disorder that also affects the heart, eyes, bones, kidneys, vasculature and other organs

2

Individuals with AGS may have characteristic facial features, including prominent forehead and pointed chin, deep-set eyes and a straight nose

3

An estimated 15% of people diagnosed with Alagille syndrome are at risk of severe liver disease and liver failure that can be life-threatening

4

A problem with the JAG1 gene - usually a mutation in, but sometimes a deletion - causes more than 90% of Alagille syndrome cases

5

Itchiness is often a very challenging symptom in Alagille syndrome some patients scratch so hard and so frequently that it causes red marks, bleeding, and scarring

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