Rare Medical News

5 Facts you should know about

APDS (2)

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1

Characterized by chronic benign lymphoproliferation.

2

Recurrent sinopulmonary infections (98%)

and nonneoplastic lymphoproliferation (75%) are common manifestations.

3

Autoimmune disease symptoms include immune cytopenias,

juvenile arthritis, glomerulonephritis and sclerosing cholangitis.

4

There are varying degrees of increased IgM levels,

increased circulating transitional B cells, decreased naïve CD4 and CD8 T-cells with increased CD8 effector/memory cells.

5

Hematopoietic stem cell transplantation

is currently the only curative treatment for APDS.

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