Rare Medical News

5 Facts you should know about

APS-1

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1

APS-1 has a diverse range of symptoms,

including autoimmunity against different organs and an increased susceptibility to candidiasis.

2

Chronic mucocutaneous candidiasis (CMC) is a hallmark of APS-1.

3

The syndrome is caused by mutations

in the autoimmune regulator (AIRE) gene.

4

It presents as a group of symptoms

including potentially life-threatening endocrine and gastrointestinal dysfunctions.

5

Ectodermal dystrophy of the skin, dental enamel, and nails is often seen.

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