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5 Facts you should know about

Autoimmune polyglandular syndrome type 1

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1

Autoimmune polyglandular syndrome type 1 (APS-1) has a diverse range of symptoms, including autoimmunity against different organs and increased susceptibility to candidiasis

2

Chronic mucocutaneous candidiasis (CMC) is a hallmark of APS-1

3

The syndrome is caused by mutations in the autoimmune regulator (AIRE) gene

4

It presents as a group of symptoms including potentially life-threatening endocrine and gastrointestinal dysfunctions

5

Ectodermal dystrophy of the skin, dental enamel, and nails is often seen

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