Rare Medical News

5 Facts you should know about

Autoimmune autonomic ganglionopathy (AAG)

fivefacts-light.svg

1

Autoimmune autonomic ganglionopathy (AAG) is

an acquired immune-mediated disorder that leads to systemic autonomic failure.

2

Symptoms may include

severe orthostatic hypotension, fainting, constipation, fixed and dilated pupils, urinary retention, and dry mouth and eyes.

3

Idiopathic AAG

In idiopathic AAG, the body's own immune system targets a receptor in the autonomic ganglia, which is part of a peripheral nerve fiber.

4

Paraneoplastic

If the AAG is paraneoplastic, they have a form of cancer, and their immune system has produced paraneoplastic antibodies in response to the cancer.

5

1/3 of people with AAG get better without treament

Approximately one third of people with AAG get better without treatment, but the recovery is often incomplete.

Rare Medical News