Rare Medical News
5 Facts you should know about
Bardet-Biedl Syndrome
1
Symptoms include retinal degeneration, obesity, reduced kidney function, and polydactyly.
2
Patients with BBS can experience problems with obesity, specifically with fat deposition along the abdomen.
3
BBS patients often experience hyperphagia - an abnormally strong, incessant sensation of hunger or desire to eat often leading to overeating.
4
The melanocortin-4 receptor pathway (MC4R pathway) in the hypothalamus is responsible for regulating hunger, food intake, satiety, and energy expenditure.
5
Impaired MC4R signaling can lead to early-onset, severe obesity and hyperphagia, irrespective of environmental and lifestyle factors.
Rare Medical News