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5 Facts you should know about

Centronuclear myopathy



Centronuclear myopathy (CNM) is an umbrella term for a group of rare genetic muscle disorders


The most notable clinical manifestations of CNM are muscle weakness and associated disabilities


Symptoms are often present at birth in the severe forms, but may first develop later in life, although onset in adulthood is unusual


CNMs derive their name based on the central location of the muscle fiber (muscle cell) nucleus---cell nuclei are abnormally located in the center of muscle cells instead of their normal location at the periphery


While some patients with centronuclear myopathies remain ambulatory throughout their adult life, others may never crawl or walk and may require wheelchair use for mobility

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