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5 Facts you should know about

Cold agglutinin disease

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1

Hemolysis in CAD is driven by C1 activation of the classical complement pathway, when cold agglutinins (IgM autoantibodies) recruit and activate C1, typically at body temperatures under 98.6 °F

2

Cold agglutinin disease can be primary or secondary, due to an underlying condition such as an infection, another autoimmune disease, or certain cancers

3

Primary cold agglutinin disease occurs after the fifth decade of life and peaks prevalence in a person's 70s and 80s

4

Many people with CAD also experience pain and bluish coloring of the hands and feet (acrocyanosis) or Raynaud's disease

5

Mycoplasma pneumoniae infection is the most common cause of secondary CAD

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