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5 Facts you should know about

Cold agglutinin disease



Hemolysis in CAD is driven by C1 activation of the classical complement pathway, when cold agglutinins (IgM autoantibodies) recruit and activate C1, typically at body temperatures under 98.6 °F.


Cold agglutinin disease can be primary or secondary, due to an underlying condition such as an infection, another autoimmune disease, or certain cancers.


Primary cold agglutinin disease occurs after the fifth decade of life and peaks prevalence in a person's 70s and 80s.


Many people with CAD also experience pain and bluish coloring of the hands and feet (acrocyanosis) or Raynaud's disease.


Mycoplasma pneumoniae infection is the most common cause of secondary CAD.

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