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5 Facts you should know about

Pyruvate kinase (PK) deficiency

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1

Pyruvate kinase deficiency (PKD) is the most common type of inherited hemolytic anemia

2

PKD is caused by mutations in the PKLR gene

3

In neonates, common signs include hyperbilirubinemia and anemia

4

Older children may present with poor growth, easy fatiguability, and jaundice

5

Although the anemia tends to stabilize in adulthood, episodes of anemia may occur with acute infections, stress, and pregnancy

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