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Chagas disease

Chagas disease, also known as American trypanosomiasis, is a tropical parasitic disease caused by Trypanosoma cruzi

Prevalence

Unknown

US Estimated

Unknown

Europe Estimated

Age of Onset

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ICD-10

N/A

Inheritance

Autosomal dominant

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Autosomal recessive

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Mitochondrial/Multigenic

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X-linked dominant

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X-linked recessive

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Rare View

Chagas disease, also known as American trypanosomiasis, is a tropical parasitic disease caused by Trypanosoma cruzi. It is spread mostly by insects in the subfamily Triatominae, known as "kissing bugs". The symptoms change over the course of the infection. In the early stage, symptoms are typically either not present or mild, and may include fever, swollen lymph nodes, headaches, or swelling at the site of the bite. An estimated 8 million people are infected with Trypanosoma cruzi worldwide, mainly in Latin America where Chagas disease remains one of the biggest public health problems, causing incapacity in infected individuals and more than 10,000 deaths per year.

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5 Facts you should know

FACT

1

A tropical parasitic disease caused by Trypanosoma cruzi

FACT

2

It is spread mostly by insects known as Triatominae, or "kissing bugs"

FACT

3

In the early stage, symptoms are typically either not present or mild, and may include fever, swollen lymph nodes, headaches, or swelling at the site of the bite

FACT

4

The disease may also be spread through blood transfusion, organ transplantation, eating food contaminated with the parasites, and vertical transmission

FACT

5

Up to 45% of people with chronic infection develop heart disease 10–30 years after the initial illness, which can lead to heart failure

Chagas disease is also known as...

Chagas disease

American trypanosomiasis

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What is the organ most likely to be affected in the long term by people with Chagas disease?

Common signs & symptoms

Abdominal pain

 Pain in stomach

Cardiomyopathy

Disease of the heart muscle

Dyspnea

Trouble breathing

Localized skin lesion

Arrhythmia

Abnormal heart rate

Diarrhea

Watery stool

Hepatomegaly

Enlarged liver

Periorbital edema

Current treatments

Benznidazole

(Brand name: Benznidazole) Manufactured by Chemo Research, S.L.
FDA-approved indication: For use in children ages 2 to 12 years old with Chagas disease

Nifurtimox

(Brand name: LAMPIT) Manufactured by Bayer Healthcare Pharmaceuticals
FDA-approved indication: Lampit® (nifurtimox) is an antiprotozoal medication indicated for use in pediatric patients (from birth to less than 18 years of age and weighing at least 2.5 kg) for the treatment of Chagas disease (American Trypanosomiasis) caused by Trypanosoma cruzi (T. cruzi).

Top Clinical Trials

TitleDescriptionPhasesStatusInterventionsLocationsMore Information
Short-course Benznidazole Treatment to Reduce Trypanosoma Cruzi Parasitic Load in Women of Reproductive AgeThe investigators are proposing to perform a double-blinded, non-inferiority randomized controlled trial comparing a short 30-day treatment with BZN 150mg/day (30d/150mg) vs. a 60-day treatment with BZN 300 mg/day (60d/300mg). Phase 3RecruitingDrug: Benznidazole|Drug: Placebo Oral TabletUniversity of California at San Diego, San Diego, California, United States|Tulane School of Public Health and Tropical Medicine, New Orleans, Louisiana, United States|Institute for Clinical Effectiveness and Health Policy, Buenos Aires, ArgentinaMore Information

Top Treatments in Research

At the time this analysis was conducted, there were no treatments in development for this disease.

Centers for Disease Control and Prevention